1436433-80-5

Basic information

• Product Name: C₁₆H₁₁Cl₂N₃OS₂
• CAS NO: 1436433-80-5
• Molecular Weight: 396.321
• Mol File: 1436433-80-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₁Cl₂N₃OS₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₁Cl₂N₃OS₂(1436433-80-5)
• EPA Substance Registry System: C₁₆H₁₁Cl₂N₃OS₂(1436433-80-5)

Safety Data

• Hazardous Substances Data: 1436433-80-5(Hazardous Substances Data)

Upstream product

• 175135-07-6 benzo[b]thiophene-2-carboxylic acid hydrazide 
• 701919-78-0 3,4-dichloroaniline 
• 95-76-1 m,p-dichloroaniline 

Downstream Products

• 1436433-75-8 C₁₈H₁₁Cl₂N₃O₂S₂ 
• 1436433-89-4 C₁₆H₉Cl₂N₃S₂ 

Relevant articles and documents

Discovery of protein-protein interaction inhibitors of replication protein A

Replication protein A (RPA) is a ssDNA binding protein that is essential for DNA replication and repair. The initiation of the DNA damage response by RPA is mediated by protein-protein interactions involving the N-terminal domain of the 70 kDa subunit with partner proteins. Inhibition of these interactions increases sensitivity toward DNA damage and replication stress and may therefore be a potential strategy for cancer drug discovery. Toward this end, we have discovered two lead series of compounds, derived from hits obtained from a fragment-based screen, that bind to RPA70N with low micromolar affinity and inhibit the binding of an ATRIP-derived peptide to RPA. These compounds may offer a promising starting point for the discovery of clinically useful RPA inhibitors.