143653-61-6

Basic information

• Product Name: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-5-methyl-
• CAS NO: 143653-61-6
• Molecular Formula: C31H32N2O7
• Molecular Weight: 544.604
• Mol File: 143653-61-6.mol

Chemical Properties

• CAS DataBase Reference: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-5-methyl-(143653-61-6)
• EPA Substance Registry System: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-5-methyl-(143653-61-6)

Safety Data

• Hazardous Substances Data: 143653-61-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-5-methylis used as a therapeutic agent for neurological disorders and cognitive decline due to its potential neuroprotective and neurotrophic effects. It may help in the treatment of conditions such as Alzheimer's disease and other neurodegenerative disorders by supporting the health and function of neurons.
Used in Research Applications:
This modified uridine compound is used in research settings to study its potential therapeutic effects and mechanisms of action. Further research is ongoing to explore the full therapeutic potential of Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-5-methyl- and to better understand its role in treating neurological disorders and cognitive decline.

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 7084-29-9 3'-deoxy-5-methyluridine 
• 415704-30-2 1,2-di-O-acetyl-5-O-(methoxycarbonyl)-3-deoxy-D-erythro-pentofuranose 
• 854389-54-1 1-(2-O-acetyl-3-deoxy-5-O-methoxycarbonyl-β-D-erythropentofuranosyl)-5-methyluracil 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 4613-71-2 5-O-benzoyl-3-deoxy-1,2-di-O-acetyl-α,β-D-erythro-pentofuranose 
• 143653-60-5 2'-O-acetyl-5'-O-benzoyl-3'-deoxy-5-methyluridine 
• 1463-10-1 5-Methyluridine 
• 138239-62-0 1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 114551-15-4 5'-O-(4,4'-dimethoxytrityl)-1-(3-deoxy-β-D-arabinofuranosyl)thymine 
• 1572186-20-9 C₃₇H₄₅N₂O₁₀P 
• 171603-30-8 C₃₃H₃₄N₂O₈ 
• 1572186-18-5 C₃₄H₃₈N₂O₉ 
• 171603-29-5 C₃₄H₃₆N₂O₇ 
• 854389-55-2 [(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxymethyl]-phosphonic acid monomethyl ester 
• 142103-12-6 Diisopropyl-phosphoramidous acid (2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 

Relevant articles and documents

SHORT INTERFERING NUCLEIC ACID (siNA) MOLECULES CONTAINING A 2' INTERNUCLEOSIDE LINKAGE

The present invention relates to RNAi molecules, and compositions thereof, comprising a 2′ internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5′ end of the antisense strand. Specifically, the invention

Nucleosidyl-O-methylphosphonates: A pool of monomers for modified oligonucleotides

An unique set of 5′-O- and 3′-O-phosphonomethyl derivatives of four natural 2′-deoxyribonucleosides, 1-(2-deoxy-β-D-threo- pentofuranosyl)thymine, 5′-O- and 2′-O-phosphonomethyl derivatives of 1-(3-deoxy-β-D-erythro-pentofuranosyl)thymine, and 1-(3-deoxy-β-D- threo-pentofuranosyl)thymine has been synthesized as a pool of monomers for the synthesis of modified oligonucleotides. The phosphonate moiety was protected with 4-methoxy-1-oxido-2-pyridylmethyl ester group, serving also as an intramolecular catalyst in the coupling step.

3'-Deoxy-2'-phosphoramidites of adenosine and 5-methyluridine used for the solid phase synthesis of unnatural 3'-deoxy-2'-5''-oligonucleotides

Protected phosphoramidites of 3'-deoxyadenosine and 3'-deoxy-5-methyluridine have been synthesized, and used in solid phase synthesis of 3'-deoxyoligonucleotides with the unusual 2'-5'' linkage.