1436595-76-4Relevant academic research and scientific papers
Transition-metal-free synthesis of aryl-substituted tert-butyl ynol ethers through addition/elimination substitution at an sp centre
Gray, Vincent J.,Slater, Ben,Wilden, Jonathan D.
, p. 15582 - 15585 (2013/01/16)
Nucleophilic attack of an alkoxide on an alkynyl sulfonamide leads to displacement of the sulfonamide at the sp centre and isolation of the ynol ether in good yield in a single operation (see scheme). The mechanistic pathway has been probed by the use of coordinating additives, 13C-labelling experiments and ab initio calculations, which indicated that an addition/elimination mechanism is in operation. Copyright
