143662-55-9Relevant academic research and scientific papers
Intramolecular addition of acyldiazenecarboxylates onto double bonds in the synthesis of heterocycles
Prata, Jose V.,Clemente, Dina-Telma S.,Prabhakar, Sundaresan,Lobo, Ana M.,Mourato, Isabel,Branco, Paula S.
, p. 513 - 528 (2007/10/03)
Appropriate aryl-substituted unsymmetrical azodicarbonyl compounds, generated from bishydrazides by oxidation, undergo intramolecular cyclisations to furnish a variety of useful heterocycles such as N-substituted oxindoles, carbostyrils, benzazepinones, benzazocinones, benzimidazolones, benzoxazinones and pyrazolones in varying degrees of efficiency. Methods are described to remove the N-acyl groups from the heteroaromatic compounds. Under mildly acidic conditions where equal opportunities are available for an ipso or a normal cyclisation it is the former process that occurs preferentially. Evidence is presented in favour of a C-to-C migration in the ipso product for the formation of a methoxy-substituted carbostyril derivative. One of the spiro substances is shown to participate in dienone-phenol rearrangement to provide the corresponding quinolone-phenol in high yield.
Remarkably Efficient Hydrolysis of a 4-Nitrophenyl Ester by a Catalytic Antibody Raised to an Ammonium Hapten
Khalaf, Abedawn I.,Proctor, George R.,Suckling, Colin J.,Bence, Laura H.,Irvine, June I.,Stimson, William H.
, p. 1475 - 1482 (2007/10/02)
Antibodies have been raised to a 1-benzazepine hapten and the properties of two of the strongly binding clones, designated C3 and C5, as catalysts examined.Neither antibody catalysed the reaction for which they were first generated, electrophilic substitu
Studies in Antifertility Agents: Part XXXIII- Synthesis of 1,2-trans-1--2-benzyl-7-methoxybenzosuberan
Sangwan, Naresh K.,Rastogi, Shri Nivas
, p. 140 - 143 (2007/10/02)
Condensation of 7-methoxy-1-benzosuberone (4) with PhCHO gives 2-benzylidene derivative (5) which on hydrogenation over Pd-C affords the corresponding 2-benzyl analog (6).Reduction of 6 with KBH4 furnishes a mixture of 1,2-cis- and trans-2-benzyl-1-benzos
