143667-11-2

Upstream product

• 132428-16-1 3-((1,4a-dimethyl-7-(1-methylethyl)-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenyl)methylamino)-1-(4-fluorophenyl)-1-propanone hydrochloride 
• 143667-14-5 3-([1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro7-(1-methylethyl)-1-phenanthrenyl]methylamino)-1-(4-fluorophenyl)-1-propanone 
• 24978-68-5 18-aminoabieta-8,11,13-triene 

Relevant academic research and scientific papers

Anti-inflammatory phospholipase-A2 inhibitors. II. Design, synthesis and structure-activity relationship

The design and synthesis of a novel series of phospholipase-A2 (PLA2) inhibitor with antiinflammatory activity was based on a systematic structure-activity relationship (SAR) analysis.

Antiinflammatory phospholipase-A2 inhibitors. I.

A novel series of dehydroabietylamine derivatives has been synthesized and shown to be inhibitors of phospholipase-A2 (PLA2). These compounds exhibit in vivo antiinflammatory activity in the rat carrageenan paw edema assay and support the concept of PLA2 inhibition as an approach to the discovery of novel antiinflammatories.