1436689-52-9Relevant articles and documents
7-Phenyl-imidazoquinolin-4(5H)-one derivatives as selective and orally available mPGES-1 inhibitors
Shiro, Tomoya,Kakiguchi, Keisuke,Takahashi, Hirotada,Nagata, Hidetaka,Tobe, Masanori
, p. 2868 - 2878 (2013/06/27)
To identify compounds with strong mPGES-1 inhibitory activity and clear in vitro ADME profile, we optimized the lead compound 1 by carrying our substitutions at the C(7)- and C(8)-positions. Replacement of the bromine atom of 1 with various substituents l