14367-47-6 Usage
Uses
Used in Pharmaceutical Industry:
Mebeverine alcohol is used as an active metabolite for its antispasmodic properties. As a result of its derivation from Mebeverine, an antispasmodic, mebeverine alcohol can be utilized in the development of medications aimed at treating muscle spasms and related conditions. Its light yellow oil form may also contribute to its effectiveness in pharmaceutical formulations.
Used in Chemical Research:
Mebeverine alcohol, being a metabolite with unique chemical properties, can be employed as a subject of study in chemical research. Researchers can investigate its potential interactions with other compounds, its stability, and its reactivity, which may lead to the discovery of new applications or improvements in existing pharmaceutical formulations.
Used in Drug Development:
Given its origin as a metabolite of an antispasmodic agent, mebeverine alcohol can be used in drug development for creating new medications or enhancing the efficacy of existing ones. Its chemical properties may offer advantages in terms of bioavailability, targeting specific conditions, or reducing side effects when compared to other compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 14367-47-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,3,6 and 7 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 14367-47:
(7*1)+(6*4)+(5*3)+(4*6)+(3*7)+(2*4)+(1*7)=106
106 % 10 = 6
So 14367-47-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H27NO2/c1-4-17(11-5-6-12-18)14(2)13-15-7-9-16(19-3)10-8-15/h7-10,14,18H,4-6,11-13H2,1-3H3
14367-47-6Relevant academic research and scientific papers
First derivative synchronous fluorescence spectroscopy for the simultaneous determination of sulpiride and mebeverine hydrochloride in their combined tablets and application to real human plasma
Walash,Sharaf El-Din,El-Enany, Nahed,Eid,Shalan, Sh.
experimental part, p. 1275 - 1285 (2011/11/13)
A rapid, simple and highly sensitive first derivative synchronous fluorometric method has been developed for the simultaneous analysis of binary mixture of sulpiride (SUL) and mebeverine hydrochloride (MEB). The method is based upon measurement of the synchronous fluorescence intensity of these drugs at Δλ=100 nm in water. The different experimental parameters affecting the fluorescence of the two drugs were carefully studied and optimized. The fluorescence-concentration plots were rectilinear over the range of 0.05-1 μg/mL and 0.2-3.2 μg/mL for SUL and MEB respectively with lower detection limits (LOD) of 0.006 and 0.01 μg/mL and quantification limits (LOQ) of 0.0.02 and 0.05 μg/mL for SUL and MEB, respectively. The proposed method was successfully applied for the determination of the two compounds in synthetic mixtures and in commercial tablets. The high sensitivity attained by the proposed method allowed the determination of both of SUL and MEB metabolite (veratic acid) in real human plasma samples applying second derivative synchronous fluorometric technique. The mean% recoveries (n=3) for both MEB metabolite (veratic acid) and SUL were 99.82±2.53 and 98.84±6.20 for spiked human plasma respectively, while for real human plasma, the mean% recoveries (n=3) were 91.49±4.25 and 91.36±8.46 respectively.
