1436799-45-9Relevant academic research and scientific papers
Targeting the Hsp90 chaperone: Synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90
Day, James E. H.,Sharp, Swee Y.,Rowlands, Martin G.,Aherne, Wynne,Workman, Paul,Moody, Christopher J.
, p. 2758 - 2763 (2010)
A series of benzo-macrolactones has been prepared by chemical synthesis, and evaluated as inhibitors of heat shock protein 90 (Hsp90), an emerging attractive target for novel cancer therapeutic agents. A new synthesis of these resorcylic acid macrolactone analogues of the natural product radicicol is described in which the key steps are the acylation and ring opening of a homophthalic anhydride to give an isocoumarin, followed by a ring-closing metathesis to form the macrocycle. The methodology has been extended to a novel series of macrolactones incorporating a 1,2,3-triazole ring.
An improved synthesis of resorcylic acid macrolactone inhibitors of Hsp90
Day, James E. H.,Blake, Alexander J.,Moody, Christopher J.
scheme or table, p. 1567 - 1570 (2009/11/30)
A synthesis of resorcylic acid macrolactone analogues of the natural product radicicol is described in which the key steps are the acylation and ring opening of a homophthalic anhydride to give an isocoumarin, followed by a ring-closing metathesis to form
