1436840-94-6

Basic information

• Product Name: 5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-(4-fluoro-phenyl)-furo[3,2-h]quinolin-9-ium bromide
• Synonyms: 5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-(4-fluoro-phenyl)-furo[3,2-h]quinolin-9-ium bromide
• CAS NO: 1436840-94-6
• Molecular Weight: 496.763
• Mol File: 1436840-94-6.mol

Chemical Properties

• CAS DataBase Reference: 5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-(4-fluoro-phenyl)-furo[3,2-h]quinolin-9-ium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-(4-fluoro-phenyl)-furo[3,2-h]quinolin-9-ium bromide(1436840-94-6)
• EPA Substance Registry System: 5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-(4-fluoro-phenyl)-furo[3,2-h]quinolin-9-ium bromide(1436840-94-6)

Safety Data

• Hazardous Substances Data: 1436840-94-6(Hazardous Substances Data)

Upstream product

• 1218818-89-3 5-chloro-2-(4-fluorophenyl)furo[3,2-h]quinoline 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 1436841-47-2 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylic acid ethyl ester 
• 1436841-37-0 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8,9-dicarboxylic acid dimethyl ester 
• 1436841-42-7 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8,9-dicarboxylic acid diethyl ester 
• 1436841-52-9 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylic acid ethyl ester 

Relevant articles and documents

Traceless synthetic approach towards oxaza-dicyclopenta[a,h]naphthalenes under solvent-free condition: A basic alumina-supported green protocol

A novel class of oxaza-dicyclopenta[a,h]naphthalenes was efficiently constructed from furo[3,2-h]quinoliniums through a 1,3-dipolar cycloaddition reaction employing basic alumina as the solid support. The distinguished features of this methodology encompa

Synthesis and characterization of furo[3,2-h]quinoliniums as potent non-detergent spermicides

7-Aryl substituted furo[3,2-h]quinoliniums have been synthesised in two steps from 5-chloro-8-hydroxy-7- iodo-quinoline through a tandem Sonogashira alkynylation-cyclization pathway using aryl acetylenes followed by quaternisation reaction with alkyl halides under microwave irradiation. The compounds have been characterized spectroscopically and assessed for their sperm-immobilizing efficacy in vitro by modified Sander-Cramer test. Most of the derivatives showed potent spermicidal effect with minimum effective concentration (MEC) ranging from 125μg/ml - 1mg/ml. The results were further confirmed by double fluoroprobe staining with syber14/PI (Propidium Iodide). The mode of spermicidal action was assessed by (a) Hypo-osmotic swelling tests and (b) Scanning electron microscopy. The compounds have been found to be nontoxic to lactobacillus in 36 hours of culture whereas mild to moderately effective on common vaginal pathogens. Taken together it can be inferred that the water-soluble salts prepared from facile technique are potential candidates for spermicides and could further be utilized for the preparation of vaginal contraceptives.