1436849-52-3Relevant academic research and scientific papers
Ruthenium-catalyzed direct arylation of C-H bonds in aromatic amides containing a bidentate directing group: Significant electronic effects on arylation
Aihara, Yoshinori,Chatani, Naoto
, p. 664 - 670 (2013/03/29)
Arylation of ortho C-H bonds is achieved by a ruthenium-catalyzed reaction of aromatic amides having an 8-aminoquinoline moiety with aryl bromides. The reaction shows high functional group compatibility. The reaction proceeds in a highly selective manner at the less hindered C-H bonds of meta-substituted aromatic amides. Significant electronic effects are observed in Hammett plots. Electron-withdrawing groups on the aromatic amides facilitate the reaction. In contrast, both electron-donating groups and electron-withdrawing groups on aryl bromides accelerate the reaction. The Royal Society of Chemistry 2013.
