143685-68-1

Basic information

• Product Name: 2-Propenamide,N-(3-pyridinyl)-(9CI)
• Synonyms: 2-Propenamide,N-(3-pyridinyl)-(9CI)
• CAS NO: 143685-68-1
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.16192
• Product Categories: PYRIDINE
• Mol File: 143685-68-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenamide,N-(3-pyridinyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide,N-(3-pyridinyl)-(9CI)(143685-68-1)
• EPA Substance Registry System: 2-Propenamide,N-(3-pyridinyl)-(9CI)(143685-68-1)

Safety Data

• Hazardous Substances Data: 143685-68-1(Hazardous Substances Data)

Usage

General Description

2-Propenamide, N-(3-pyridinyl)-(9CI) is a chemical compound with the molecular formula C8H8N2O. It is a member of the pyridine family and is used in pharmaceutical and industrial applications. 2-Propenamide,N-(3-pyridinyl)-(9CI) is a derivative of acrylic acid and contains a pyridine ring, which gives it unique chemical properties. It can act as a ligand in coordination chemistry and has been studied for its potential as a building block in the synthesis of bioactive compounds. Additionally, it has been investigated for its potential use as an inhibitor in enzyme-catalyzed reactions. Overall, 2-Propenamide, N-(3-pyridinyl)-(9CI) is a versatile chemical with various potential applications in the fields of medicine and chemistry.

Upstream product

• 462-08-8 pyridin-3-ylamine 
• 814-68-6 acryloyl chloride 

Relevant articles and documents

N-(6-Methyl-2-pyridyl)acrylamide: a case of amide hydrolysis without the assistance of acid or base in the synthesis of water-driven H-bonded polymeric chains

Amide hydrolysis of N-(6-methyl-2-pyridyl)acrylamide without the assistance of either acid or base produces the aminopyridinium carboxylate salt at low or room temperature. The carboxylate ion and the free amine functionalities are cooperatively involved in hydrogen bonding with lattice water to form a new hydrogen-bonded polymeric chain.

Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes

Single electron reduction is more challenging for sulfamoyl chlorides than sulfonyl chlorides. However, sulfamoyl and sulfonyl chlorides can be easily activated by Cl-atom abstraction by a silyl radical with similar rates. This latter mode of activation was therefore selected to access aliphatic sulfonamides, applying a single-step hydrosulfamoylation using inexpensive olefins, tris(trimethylsilyl)silane, and photocatalyst Eosin Y. This late-stage functionalization protocol generates molecules as complex as sulfonamide-containing cyclobutyl-spirooxindoles for direct use in medicinal chemistry.