14369-15-4Relevant academic research and scientific papers
DIRECT AMINATION OF 3(2H)-PYRIDAZINONES: RE-INVESTIGATION OF THE REACTION OF 3,6-DIMETHOXYPYRIDAZINE WITH HYDRAZINE
Coates, William J.,McKillop, Alexander
, p. 1313 - 1329 (2007/10/02)
3,6-Dimethoxypyridazine has been shown to react with hydrazine via 4-amination of 6- methoxy and 6-hydrazino-3(2H)-pyridazinones to give 4-amino-6-methoxy- and 4-amino-6-hydrazino-3(2H)-pyridazinones, and not the corresponding 5-amino isomers as previously reported.The published synthesis of the 5-amino isomers, used to confirm the earlier findings, is incorrect as regards 5-amino-6-hydrazino-3(2H)-pyridazinone, which has been prepared by an alternative route.The 4-aminnation reaction has been extended to 6-chloro-3(2H)-pyridazinone.
