143698-00-4Relevant academic research and scientific papers
Lewis Acid-Promoted Reaction of β,β-Difluorinated N,O-Acetal with Silylated Nucleophiles
Tsukamoto, Takashi,Kitazume, Tomoya
, p. 1377 - 1380 (2007/10/02)
Lewis acid-promoted reaction of ethyl 3-ethoxy-2,2-difluoro-3-(dimethylamino)propionate (1) with some silylated nucleophiles afforded β,β-difluoroamines in good yields.The formation of iminium ion intermediate from 1 and BF3*OEt2 was confirmed by 19F and 13C NMR spectroscopy.
