1437052-82-8

Basic information

• Product Name: 2-(2,5-bis(2-(ethoxymethoxy)propan-2-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• Synonyms: 2-(2,5-bis(2-(ethoxymethoxy)propan-2-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS NO: 1437052-82-8
• Molecular Weight: 436.397
• Mol File: 1437052-82-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2,5-bis(2-(ethoxymethoxy)propan-2-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,5-bis(2-(ethoxymethoxy)propan-2-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(1437052-82-8)
• EPA Substance Registry System: 2-(2,5-bis(2-(ethoxymethoxy)propan-2-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(1437052-82-8)

Safety Data

• Hazardous Substances Data: 1437052-82-8(Hazardous Substances Data)

Usage

Class

Boron-containing heterocycles

Primary use

Reagent in organic synthesis

Specific applications

Formation of carbon-carbon and carbon-heteroatom bonds

Structure

Consists of boron, oxygen, and carbon atoms

Value

Building block for pharmaceuticals, agrochemicals, and materials in organic chemistry

Functional groups

Ethoxymethoxy and methyl groups

Versatility

Important tool for the development of new chemical reactions and processes

Research and development

Valuable and widely studied compound in the field of chemical research and development.

Upstream product

• 1437052-79-3 2-bromo-1,4-bis(2-(ethoxymethoxy)propan-2-yl)benzene 
• 73183-34-3 bis(pinacol)diborane 
• 87808-49-9 2-bromo-4-methyl-benzoic acid methyl ester 
• 7697-27-0 2-bromo-4-methylbenzoic acid 
• 1437052-76-0 2,2'-(2-bromo-1,4-phenylene)dipropan-2-ol 
• 18643-86-2 dimethyl 2-bromoterephthalate 
• 264272-63-1 2-bromo-1,4-benzenedicarboxylic acid,1-methyl ester 

Downstream Products

• 1437049-95-0 N-(2-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)propan-2-yl)-2-methyl-4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzamide 
• 1437051-38-1 N-(2-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)propan-2-yl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxamide 

Relevant articles and documents

Optimization of isoxazoline amide benzoxaboroles for identification of a development candidate as an oral long acting animal ectoparasiticide

Novel isoxazoline amide benzoxaboroles were designed and synthesized to optimize the ectoparasiticide activity of this chemistry series against ticks and fleas. The study identified an orally bioavailable molecule, (S)-N-((1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methyl)-2-methyl-4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzamide (23), with a favorable pharmacodynamics profile in dogs (Cmax = 7.42 ng/mL; Tmax = 26.0 h; terminal half-life t1/2 = 127 h). Compound 23, a development candidate, demonstrated 100% therapeutic effectiveness within 24 h of treatment, with residual efficacy of 97% against American dog ticks (Dermacentor variabilis) on day 30 and 98% against cat fleas (Ctenocephalides felis) on day 32 after a single oral dose at 25 mg/kg in dogs.