143708-26-3

Basic information

• Product Name: 2-(CHLOROMETHYL)-4-NITRO-1,3-BENZOXAZOLE
• Synonyms: 2-(CHLOROMETHYL)-4-NITRO-1,3-BENZOXAZOLE;2-Chloromethyl-4-nitro-benzooxazole
• CAS NO: 143708-26-3
• Molecular Formula: C₈H₅ClN₂O₃
• Molecular Weight: 212.5899
• Product Categories: Methyl Halides;Oxazoles, Isoxazoles & Benzoxazoles;Methyl Halides;Oxazoles, Isoxazoles & Benzoxazoles
• Mol File: 143708-26-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 98-100
• Appearance: /
• CAS DataBase Reference: 2-(CHLOROMETHYL)-4-NITRO-1,3-BENZOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROMETHYL)-4-NITRO-1,3-BENZOXAZOLE(143708-26-3)
• EPA Substance Registry System: 2-(CHLOROMETHYL)-4-NITRO-1,3-BENZOXAZOLE(143708-26-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 143708-26-3(Hazardous Substances Data)

Usage

General Description

2-(Chloromethyl)-4-nitro-1,3-benzoxazole is a chemical compound characterized by its structure that combines elements of chloromethyl, nitro and benzoxazole. Its molecular formula is C8H6ClN3O3, indicating that it contains carbon, hydrogen, chlorine, nitrogen and oxygen atoms. Due to the presence of the benzoxazole and chloromethyl groups, this compound usually exhibits aromaticity and interesting reactivity which can be utilized in various chemical reactions or processes. Its properties can largely depend on the environmental factors and reaction conditions. This chemical is generally used in the field of advanced research and development in organic chemistry.

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Relevant articles and documents

COMPOUNDS HAVING PDE9A INHIBITORY ACTIVITY, AND PHARMACEUTICAL USES THEREOF

The present invention provides a compound having a specific chemical structure and having PDE9A inhibitory activity, or a pharmaceutically acceptable salt thereof. The present invention provides a composition containing the compound or a pharmaceutically acceptable salt thereof. The present invention provides a pharmaceutical use, for treating or preventing PDE9A-related diseases, of the compound according to the present invention, a salt thereof, and a composition containing the compound or salt. The present invention also provides a method for treating or preventing PDE9A-related diseases, the method comprising administering an effective amount of the compound according to the present invention, a salt thereof, or a composition containing the compound or salt to a subject in need of treatment.

Synthesis and Evaluation of 2-Pyridinone Derivatives as HIV-1-Specific Reverse Transcriptase Inhibitors. 2. Analogues of 3-Aminopyridin-2(1H)-one

A series of nonnulceoside 3-aminopyridin-2(1H)-one derivatives was synthesized and evaluated for HIV-1 RT inhibitory properties.Several analogs proved to be potent and highly selective antagonists with in vitro IC50 values as low as 19 nM in the enzyme assay using rC*dG as template*primer.Two compounds from this series, 3-amino>-5-ethyl-6-methylpyridin-2(1H)-one (34, L-697,639) and the corresponding 4,7-dichloro analogue (37, L-697,661) inhibited the spread of HIV-1 IIIb infection by 95percent in MT4 cell culture at concentrations of 25-50 nM and were selected for clinical trials as antiviral agents.