143724-97-4

Basic information

• Product Name: (1R,4S,6R)-4-((E)-Styryl)-3,7-dioxa-bicyclo[4.1.0]heptan-2-one
• Synonyms: (1R,4S,6R)-4-((E)-Styryl)-3,7-dioxa-bicyclo[4.1.0]heptan-2-one
• CAS NO: 143724-97-4
• Molecular Weight: 216.236
• Mol File: 143724-97-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1R,4S,6R)-4-((E)-Styryl)-3,7-dioxa-bicyclo[4.1.0]heptan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,4S,6R)-4-((E)-Styryl)-3,7-dioxa-bicyclo[4.1.0]heptan-2-one(143724-97-4)
• EPA Substance Registry System: (1R,4S,6R)-4-((E)-Styryl)-3,7-dioxa-bicyclo[4.1.0]heptan-2-one(143724-97-4)

Safety Data

• Hazardous Substances Data: 143724-97-4(Hazardous Substances Data)

Upstream product

• 122046-62-2 (S)-goniothalamin 
• 143724-93-0 (S)-5-Hydroxy-7-phenyl-7-phenylsulfanyl-hept-2-ynoic acid methyl ester 
• 143724-94-1 (Z)-(S)-5-Hydroxy-7-phenyl-7-phenylsulfanyl-hept-2-enoic acid methyl ester 
• 143724-91-8 (S)-1-Phenyl-1-phenylsulfanyl-6-trimethylsilanyl-hex-5-yn-3-ol 
• 143724-96-3 (S)-6-(2-Benzenesulfinyl-2-phenyl-ethyl)-5,6-dihydro-pyran-2-one 
• 143724-95-2 (S)-6-(2-Phenyl-2-phenylsulfanyl-ethyl)-5,6-dihydro-pyran-2-one 
• 143724-92-9 (S)-1-Phenyl-1-phenylsulfanyl-hex-5-yn-3-ol 
• 148516-14-7 (S)-2-(3-trimethylsilyl-2-propynyl)oxirane 
• 148516-13-6 (S)-1-chloro-2-hydroxy-5-trimethylsilyl-4-pentyne 
• 831-91-4 Benzyl phenyl sulfide 
• 14371-10-9 (E)-3-phenylpropenal 
• 665003-66-7 (1S)-1-[(E)-2-phenylvinyl]but-3-enyl acrylate 
• 172925-28-9 trans-(S)-1-phenyl-1,5-hexadien-3-ol 

Downstream Products

• 70633-85-1 (4R,6S,1'E)-4-hydroxy-6-(2'-phenylvinyl)-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 171598-87-1 (E)-(3R,5S)-Methyl 7-phenyl-syn-3,5-(isopropylidenedioxy)heptenoate 

Relevant articles and documents

Short and efficient chemoenzymatic synthesis of goniothalamin

A high-yielding three-step synthesis of goniothalamin involving an enzymatic kinetic resolution in the presence of vinyl acrylate followed by ring-closing metathesis is discussed.

Stereocontrolled Route to the δ-Benzylidenemethyl-β-hydroxy-δ-lactone System Utilizing a New Chiral Epoxyacetylene Building Block

Stereocontrolled route to the δ-benzylidenemethyl-β-hydroxy-δ-lactone system has been developed utilizing a new epoxyacetylene building block prepared from optically active epichlorohydrin.The present synthesis allowed efficient construction of goniothalamin in natural and unnatural forms and its 3-hydroxy derivative having the essential anti-β/δ-stereochemistry for HMG Co-A reductase inhibition.