143728-93-2

Basic information

• Product Name: 1-BENZYL-4-METHYL-PYRROLIDIN-3-OL
• Synonyms: 1-BENZYL-4-METHYL-PYRROLIDIN-3-OL;trans-1-Benzyl-4-methyl-pyrrolidin-3-ol
• CAS NO: 143728-93-2
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.272
• Mol File: 143728-93-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BENZYL-4-METHYL-PYRROLIDIN-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-4-METHYL-PYRROLIDIN-3-OL(143728-93-2)
• EPA Substance Registry System: 1-BENZYL-4-METHYL-PYRROLIDIN-3-OL(143728-93-2)

Safety Data

• Hazardous Substances Data: 143728-93-2(Hazardous Substances Data)

Usage

Class

Phenylmethylamines

Derivative

Pyrrolidinol derivative

Structural Feature

Benzyl group attached to the nitrogen atom of the pyrrolidin-3-ol ring

Applications

Synthesis of various pharmaceuticals

Role

Precursor in the production of other chemical compounds

Field of Interest

Medicinal chemistry and drug development

Reason for Interest

Unique structural and functional properties

Upstream product

• 676-58-4 methylmagnesium chloride 
• 75390-09-9 3-benzyl-6-oxa-3-azabicyclo[3.1.0]-hexane 

Downstream Products

• 137172-64-6 (3R,4S)-N-benzyl-3-hydroxy-4-methylpyrrolidine 
• 137172-65-7 (3S,4R)-N-benzyl-3-hydroxy-4-methylpyrrolidine 
• 69498-29-9 (-)-(3R)-N-benzyl-3-methylpyrrolidine 
• 144043-21-0 N-benzyl-3-<<(methylthio)thiocarbonyl>oxy>-4-methylpyrrolidine 
• 137172-68-0 (3S,4R)-N-benzyl-3-azido-4-methylpyrrolidine 
• 137106-07-1 (3S,4S)-N-benzyl-3-azido-4-methylpyrrolidine 
• 137172-66-8 (3R,4R)-N-benzyl-3-azido-4-methylpyrrolidine 
• 137172-67-9 (3R,4S)-N-benzyl-3-azido-4-methylpyrrolidine 
• 137106-08-2 Toluene-4-sulfonic acid (3S,4R)-1-benzyl-4-methyl-pyrrolidin-3-yl ester 
• 137106-08-2 Toluene-4-sulfonic acid (3R,4S)-1-benzyl-4-methyl-pyrrolidin-3-yl ester 

Relevant articles and documents

Fluoronaphthyridines and -quinolines as Antibacterial Agents. 5. Synthesis and Antimicrobial Activity of Chiral 1-tert-Butyl-6-fluoro-7-substituted-naphthyridones

A series of novel 7-substituted-1-tert-butyl-6-fluoronaphthyridone-3-carboxylic acids has been prepared.These derivatives are characterized by chiral aminopyrrolidine substituents at the 7 position.In this paper we report the full details of the asymmetric synthesis of this series of compounds.Structure-activity relationship studies indicate that the absolute stereochemistry at the asymmetric centers of the pyrrolidine ring is critical for maintaining good activity.Compounds 60 and 61 (3-amino-4-methylpyrrolidine enantiomers) were selected for preclinical evaluation.