143731-90-2Relevant academic research and scientific papers
Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol
Finke,Shah,Ashe,Ball,Blacklock,Bonney,Brause,Chandler,Cotton,Davies,Dellea,Dorn Jr.,Fletcher,O'Grady,Hagmann,Hand,Knight,Maycock,Mumford,et al.
, p. 3731 - 3744 (2007/10/02)
Human leukocyte elastase (HLE) is a serine protease which has been implicated as a causative agent in several pulmonary diseases. The continued modification of our previously reported cephalosporin-based HLE inhibitors has led to the identification of a s
