143741-22-4Relevant academic research and scientific papers
Lipidic peptides. V: Penicillin and cephalosporin acid conjugates with increased lipophilic character
Hughes,Toth,Ward,McColm,Cox,Anderson,Gibbons
, p. 845 - 847 (1992)
Lipophilic, double-ester derivatives of β-lactam antibiotics with methylene, ethylene, and propylene spacers were prepared by crown-ether- assisted coupling of halogenoalkyl esters of 2-(tert- butoxycarbonylamino)decanoic acid to either penicillin G or cefuroxime. The hydroxyethyl ester of penicillin G and the tert-butoxypropyl ester of cefuroxime were also prepared. The lipophilic, double-ester conjugates, the hydroxyethyl ester of penicillin G, and the tert-butoxypropyl ester of cefuroxime showed weak or no antibiotic activity in vitro, as expected. The lipophilic penicillin G conjugates and the tert-butoxypropyl ester of cefuroxime were active in vivo against a nonpenicillinase-producing strain of Staphylococcus aureus after subcutaneous administration. The penicillin G double ester with propylene spacer and the tert-butoxypropyl ester of cefuroxime were inactive in vitro, a fact indicating that both compounds were hydrolyzed in vivo, as desired. After oral administration, the lipophilic, double-ester conjugate of penicillin G with methylene spacer and the tert- butoxypropyl ester of cefuroxime were active.
