143747-01-7

Upstream product

• 5856-77-9 2,2-dimethylbutanoyl chloride 
• 143746-99-0 6(R)-<2-<8(R)-hydroxy-2(S),6(S)-dimethyl-7(S)-<1(S)-<(tert-butyldimethylsilyl)oxy>benzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 79902-31-1 (4R,6R)-6-[2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthyl)ethyl]-4-[(tert-butyldimethylsilyl)oxy]-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 143747-00-6 6(R)-<2-<8(R)-<(2,2-dimethylbutanoyl)oxy>-2(S),6(S)-dimethyl-7(S)-<1(S)-<(tert-butyldimethylsilyl)oxy>benzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 1027304-15-9 (2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-[2-((1S,2S,6S,8aR)-2,6-dimethyl-8-trimethylsilanyloxy-1,2,6,8a-tetrahydro-naphthalen-1-yl)-ethyl]-6-trimethylsilanyloxy-3,4-dihydro-2H-pyran 
• 143746-93-4 6(R)-<2-<8-<(trimethylsilyl)oxy>-2(S),6(S)-dimethyl-1,2,6,8a(R)-tetrahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyranone 
• 143746-98-9 6(R)-<2-<8-hydroxy-2(S),6(S)-dimethyl-7(S)-<1(S)-hydroxybenzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 143746-96-7 6(R)-<2-<8-oxo-2(S),6(S)-dimethyl-7(S)-<1(S)-hydroxybenzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 136432-01-4 6(R)-<2-<8-oxo-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one 

Relevant academic research and scientific papers

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs

Substitution of hydroxy and hydroxyalkyl functionality at C-7 of the hexahydronaphthalene nucleus of simvastatin has provided novel analogs. The synthetic strategy employed epoxidation or Lewis acid-catalyzed aldol reaction of the 8-keto silyl enol ether