1437788-25-4Relevant articles and documents
Generation of rhodium(I) carbenes from ynamides and their reactions with alkynes and alkenes
Liu, Renhe,Winston-Mcpherson, Gabrielle N.,Yang, Zhong-Yue,Zhou, Xin,Song, Wangze,Guzei, Ilia A.,Xu, Xiufang,Tang, Weiping
, p. 8201 - 8204 (2013/07/04)
Rh(I) carbenes were conveniently generated from readily available ynamides. These metal carbene intermediates could undergo metathesis with electron-rich or neutral alkynes to afford 2-oxopyrrolidines or be trapped by tethered alkenes to yield 3-azabicyclo[3.1.0]hexanes, a common skeleton in numerous bioactive pharmaceuticals. Although the scope of the former is limited, the latter reaction tolerates various substituted alkenes.