143799-42-2Relevant articles and documents
Practical synthesis of (Z)-polyaromatic and heteroaromatic vinylacetylenes
Hayford, Anthony,Kaloko Jr., Joseph,El-Kazaz, Salwa,Bass, Gwen,Harrison, Cheryl,Corprew, Thomas
, p. 2671 - 2673 (2007/10/03)
(Chemical Equation Presented) Two synthetic routes to several (Z)-polyaromatic and heteroaromatic substituted vinylacetylenes are described. The nature of aryl- or heteroaryl-substituted carboxaldehyde used as starting material dictated the choice of Wittig salt employed. A very attractive way to construct polyaromatic and pyridine-containing enynes is the reaction of polyaromatic and pyridine-containing aldehydes with bromomethyltriphenylphosphonium bromide in the presence of potassium tert-butoxide followed by a Sonogashira desilylation procedure (method B).
A stereoselective synthesis of 1-phenyl-1-buten-3-yne and some 1-heteroaryl analogues
Fossatelli, Marco,Van Der Kerk, Anca C. T. H. M.,Vasilevsky, Sergei F.,Brandsma, Lambert
, p. 4229 - 4232 (2007/10/02)
Z-Enynes, RCH=CHC≡CH (R= phenyl, 2-furyl, 2- and 3-thienyl and 3-pyridyl) can be obtained in ~ 40% overall yields and with a stereoselectivity of> 95% by Pd/Cu-catalyzed cross-coupling of the readily available enyne sulfide HC≡CCH=CHSC2H5