143812-41-3Relevant academic research and scientific papers
Syntheses and cytotoxicities of four stereoisomers of muricatacin from D-glucose
Yoon, Sung-Hwa,Moon, Ho-Sang,Hwang, Sung-Kwan,Choi, Seungryong,Kang, Suk-Ku
, p. 1043 - 1049 (2007/10/03)
Four stereoisomers of muricatacin 1a-d were prepared by the reaction of corresponding aldehydes 4a-d, which in turn were prepared from d-glucose, with the anion of triethylphosphonoacetate followed by reduction and cyclization under acidic conditions. Cytotoxicities of four stereoisomers were tested against in vitro A-549 cell line as well as MCF-7 cell line. Stereochemistry at C4 and C5 position of muricatacin did not affect the cytotoxicities significantly. Copyright (C) 1998 Elsevier Science Ltd.
