1438249-91-2

Upstream product

• 147905-77-9 ethyl 1-methyl-4-oxo-1-cyclohexanecarboxylate 
• 1489-97-0 ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 
• 24730-88-9 ethyl 8-methyl-1,4-dioxa-spiro[4.5]decane-8-carboxylate 
• 104036-19-3 ethyl 4-hydroxy-1-methylcyclohexane-1-carboxylate 
• 13466-38-1 5-bromopyridin-2(1H)-one 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

COMPOUNDS AS DGAT-1 INHIBITORS

Described herein are compounds of formula I. The compounds of formula I act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.

IMIDAZOLE DERIVATIVES

Disclosed herein are novel imidazole derivative compounds i.e., benzimidazole and aza-benzimidazole derivatives that act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperiipidemia, diabetes mellitus and obesity. Further disclosed are methods of treating various DGAT1 -related diseases, and the use of such imidazole compounds as described herein in the manufacture of a medicament for such treatment.