1438272-75-3Relevant academic research and scientific papers
Regioselective preparation of 3-alkoxy-4,5-difluoroanilines by S NAr
Van Brandt, Sven,Rombouts, Frederik J. R.,Martinez-Lamenca, Carolina,Leenaerts, Jos,Rauws, Tom R. M.,Trabanco, Andres A.
supporting information, p. 7048 - 7052 (2013/02/21)
A simple and scalable procedure to introduce alcohols selectively at the 3-position of 3,4,5-trifluoroaniline is described. The procedure uses powdered NaOH as base and catalytic 15-crown-5 in refluxing toluene with a Dean-Stark trap. A short exploration of other nucleophiles and fluoroaryl electrophiles is also described.
