143833-49-2

Upstream product

• 872-36-6 vinylene carbonate 
• 143833-47-0 (S)-1-((S)-1-Phenyl-ethyl)-aziridine-2-carboxylic acid 4-methoxy-phenyl ester 
• 143833-48-1 (R)-1-((S)-1-Phenyl-ethyl)-aziridine-2-carboxylic acid 4-methoxy-phenyl ester 

Downstream Products

• 143833-50-5 (2S,3R,4S)-2-Hydroxymethyl-1-((S)-1-phenyl-ethyl)-pyrrolidine-3,4-diol 

Relevant academic research and scientific papers

Chiral synthesis of both enantiomers of 1,4-dideoxy-1,4-iminolyxitol and 1,4-dideoxy-1,4-iminoribitol

Reaction of 2,3-dibromopropionyl chloride with 4-methoxyphenol and (S)-1-methylbenzylamine yielded a 4:5 mixture of readily separable diastereomeric aziridine esters in an excellent yield. Both diastereomers, upon heating with vinylene carbonate, furnished four readily separable diastereomeric pyrrolidine esters, respectively, which were transformed into both enantiomers of 1,4-dideoxy-1,4-iminolyxitol and 1,4-dideoxy-1,4-iminoribitol.