1438392-89-2Relevant academic research and scientific papers
Insights into the structural patterns of the antileishmanial activity of bi- and tricyclic N-heterocycles
Herrera, Lizzi,Stephens, David E.,D'Avila, Abigail,George, Kathryn G.,Arman, Hadi,Zhang, Yu,Perry, George,Lleonart, Ricardo,Larionov, Oleg V.,Fernández, Patricia L.
supporting information, p. 7053 - 7060 (2016/07/30)
The influence of various structural patterns in a series of novel bi- and tricyclic N-heterocycles on the activity against Leishmania major and Leishmania panamensis has been studied and compounds that are active in the low micromolar region have been identified. Both quinolines and tetrahydrooxazinoindoles (TOI) proved to have significant antileishmanial activities, while substituted indoles were inactive. We have also showed that a chloroquine analogue induces Leishmania killing by modulating macrophage activation.
Catalytic diastereo- and enantioselective annulations between transient nitrosoalkenes and indoles
Zhang, Yu,Stephens, David,Hernandez, Graciela,Mendoza, Rosalinda,Larionov, Oleg V.
, p. 16612 - 16615 (2013/03/14)
Caught in transition: An efficient catalytic system is the key to the successful development of the first highly diastereo- and enantioselective annulation reaction between indoles and transient nitrosoalkenes. This robust reaction affords structurally unique architectures with up to three new chiral centers. The products can be readily elaborated into other indoline-based chiral heterocyclic motifs, including those of pyrrolidinoindoline alkaloids. Copyright
