14384-69-1

Usage

Structure

A heterocyclic compound consisting of a pyridine ring fused to a thiazole ring with a methyl group attached to the thiazole ring.

Usage

As a building block in the synthesis of pharmaceutical compounds and agrochemicals.

Biological activities

Potential ability to inhibit certain enzymes and act as an antifungal agent.

Coordination chemistry

Used as a ligand in coordination chemistry.

Material development

Utilized in the development of new materials.

Versatility

Important chemical compound with diverse applications in various fields.

Upstream product

• 5346-38-3 pyridine-2-carbothioamide 
• 78-95-5 chloroacetone 
• 1218937-30-4 C₉H₁₀N₂S 
• 598-31-2 1-bromoacetone 
• 100-70-9 2-Cyanopyridine 

Downstream Products

• 14484-99-2 2-(4-methyl-thiazol-2-yl)-1-(2-oxo-2-phenyl-ethyl)-pyridinium; bromide 

Relevant academic research and scientific papers

Ratiometically Fluorescent Sensing of Zn(II) Based on Dual-Emission of 2-Pyridylthiazole Derivatives

A new fluorophore, 4-methyl-2-(2-pyridyl)-5-(2-thiophenyl)thiazole (2-PTT), was reported as a ratiometically fluorescent sensor of zinc(II) based on dual-emission with selectivity and sensitivity. Two emission bands at 440 and 497 nm were observed before and after addition of zinc(II), respectively. Job's plot disclosed the 1:1 stoichiometry between 2-PTT and zinc(II). The binding constant was evaluated as 2.09 × 105 M-1 based on fluorescence titration experiment.

A facile synthesis of 2,4-disubstituted thiazoles using MnO2

Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO2) oxidation of the corresponding thiazolines. The effect of substitution at the 2- and 4-positions was investigated. The desired thiazoles with aryl or vinyl substitutions at the 2- or 4-position can be obtained in good to excellent yields.