1438409-30-3Relevant academic research and scientific papers
NON-ATP DEPENDENT INHIBITORS OF EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK)
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Paragraph 0256; 0271; 0307; 0318, (2014/07/08)
A compound, having the formula A-1: Wherein R1 and R2 are defined herein. Methods of using the compound and compositions containing the compound are provided.
Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene) thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling
Jung, Kwan-Young,Samadani, Ramin,Chauhan, Jay,Nevels, Kerrick,Yap, Jeremy L.,Zhang, Jun,Worlikar, Shilpa,Lanning, Maryanna E.,Chen, Lijia,Ensey, Mary,Shukla, Sagar,Salmo, Rosene,Heinzl, Geoffrey,Gordon, Caryn,Dukes, Troy,MacKerell Jr., Alexander D.,Shapiro, Paul,Fletcher, Steven
, p. 3706 - 3732 (2013/07/05)
We herein report on the pharmacophore determination of the ERK docking domain inhibitor (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4- dione, which has led to the discovery of compounds with greater selectivities for inhibiting the proliferation of melanoma cells containing active ERK signaling. The Royal Society of Chemistry 2013.
