1438425-41-2

Upstream product

• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 
• 34328-61-5 3-Chloro-4-fluorobenzaldehyde 
• 1438425-40-1 4-(2-chloro-4-formylphenoxy)-3-methoxybenzonitrile 

Downstream Products

• 1438425-45-6 4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-hydroxybenzonitrile 
• 1438425-46-7 4-{2-chloro-4-[5-(2-hydroxyethyl)-1,2-oxazol-3-yl]phenoxy}-3-hydroxybenzonitrile 
• 1438425-47-8 1-{4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxyphenyl}methanamine 
• 1438425-48-9 N-{4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxybenzyl}-5-methyl-1,2-oxazole-3-carboxamide 
• 1438425-49-0 N-{4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-hydroxybenzyl}-5-methyl-1,2-oxazole-3-carboxamide 
• 1438425-42-3 3-chloro-4-(4-cyano-2-methoxyphenoxy)-N-hydroxybenzenecarboximidoyl chloride 
• 1438425-43-4 4-{2-chloro-4-[5-(2-tert-butyl(diphenyl)silyloxyethyl)-1,2-oxazol-3-yl]phenoxy}-3-methoxybenzonitrile 
• 1438425-44-5 4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxybenzonitrile 

Relevant academic research and scientific papers

Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides

The enoyl acyl-carrier protein reductase (ENR) enzyme is harbored within the apicoplast of apicomplexan parasites providing a significant challenge for drug delivery, which may be overcome through the addition of transductive peptides, which facilitates crossing the apicoplast membranes. The binding site of triclosan, a potent ENR inhibitor, is occluded from the solvent making the attachment of these linkers challenging. Herein, we have produced 3 new triclosan analogs with bulky A- and B-ring motifs, which protrude into the solvent allowing for the future attachment of molecular transporters for delivery.