1438463-75-2Relevant academic research and scientific papers
MODULATORS OF CASPASE-6
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Page/Page column 000135; 000149-000154, (2016/04/26)
The current application relates to a pharmaceutical composition for the treatment or amelioration of a neurological disease, wherein the composition comprises a therapeutically effective amount of a caspase-6 inhibitor which is an arylpropynamide derivative. The composition can be formulated for oral or topical administration, subcutaneous, intravenous, or intramuscular injection, infusion, inhalation, or intrthecal injection.
Preparation of arylpropynamides and their reaction with malonyl acid derivatives
Petina, Olgaa. A.,Yakovlev, Igorp. P.,Geffken, Detlef
, p. 803 - 809 (2013/04/10)
Synthesis of arylpropynamides and their reactions with different malonic acid derivatives is described. Treatment of arylpropynamides with unsubstituted malonyl chloride furnished N-(3-arylprop-2-ynoyl)-6-chloro-4-hydroxy-2-oxo-2H- pyran-3-carboxamides; m
