14385-66-1

Upstream product

• 1192-62-7 1-(2-furyl)-1-ethanone 
• 100-10-7 4-dimethylamino-benzaldehyde 

Downstream Products

• 140885-67-2 3-Cyano-4-<4-(dimethylamino)phenyl>-6-(2-furyl)-2-methylpyridine 
• 137444-86-1 6-(2-furyl)-4-(4-dimethylaminophenyl)-2-methoxynicotinonitrile 
• 685132-33-6 1-[3-(furan-2-yl)-4,5-dihydro-5-(4-N,N-dimethylaminophenyl)-pyrazol-1-yl]ethanone 

Relevant academic research and scientific papers

Antidiabetic effect of novel benzenesulfonylureas as PPAR-γ agonists and their anticancer effect

Twenty one pyrazoline containing benzenesulfonylureas were synthesized and docked against PPAR-γ target. All the compounds were first screened for their antidiabetic potential by oral glucose tolerance test and then six active compounds were assessed on S

Design and synthesis of novel pyrazoles, pyrazolines, and pyridines from chalcone derivatives with evaluation of their in vitro anticancer activity against T-47D and UACC-257 cell lines

Novel series of pyrazoline carbothioamides, acetyl pyrazoles, pyridine-3-carbonitrile, pyridine-2-carbonitriles, and nicotinonitriles were synthesized. The structures of the newly synthesized compounds were established based on their spectral data, elemen

Synthesis and selective cytotoxic activities on rhabdomyosarcoma and noncancerous cells of some heterocyclic chalcones

Chemically diverse heterocyclic chalcones were prepared and evaluated for cytotoxicity, aiming to push forward potency and selectivity. They were tested against rhabdomyosarcoma (RMS) and noncancerous cell line (LLC-PK1). The influence of heteroaryl patte

Synthesis and biologic activities of some novel heterocyclic chalcone derivatives

We synthesized 36 chalcone-like (E)-3-(substitutedphenyl)-1-hetrylprop-2- en-1-ones by condensing 2-acetylfuran/2-acetylpyrrole with substituted benzaldehydes under basic conditions. Of the 36 molecules synthesized, 10 are new to the literature. Bio-evalu

Synthesis and antibacterial activity of some heterocyclic chalcone analogues alone and in combination with antibiotics

A series of simple heterocyclic chalcone analogues have been synthesized by Claisen Schmidt condensation reactions between substituted benzaldehydes and heteroaryl methyl ketones and evaluated for their antibacterial activity. The structures of the synthe

Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones

Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are collectively known as chalcones. The cytotoxic potential of chalcones which consists of C6-C 3-C6 units gets enhanced by the incorporation of pyrazole ring as proved by our earlier studies. Thus in the present work, pyrazoles of chalcones with ring A substituted by furan, naphthalene and variety of substituted phenyl rings has been prepared and evaluated for in vitro cytotoxic activity against PC-3, OVCAR, IMR-32, HEP-2 human cancer cell lines. Springer Science+Business Media, LLC 2011.

A rational approach for the design and synthesis of 1-acetyl-3,5-diaryl-4, 5-dihydro(1H)pyrazoles as a new class of potential non-purine xanthine oxidase inhibitors

Xanthine oxidase is a complex molybdoflavoprotein that catalyses the hydroxylation of xanthine to uric acid. Fifty three analogues of 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles were rationally designed and synthesized and evaluated for in vitro xanthine

Synthesis and Characterization of Fluorescent 4,6-Disubstituted-3-cyano-2-methylpyridines

4,6-Disubstituted-3-cyano-2-methylpyridines, easily prepared by treating α,b-unsaturated carbonyl compounds with β-aminocrotononitrile in the presence of potassium tert-butoxide, have been found to show intense fluorescence in the region of 400-552 nm. 3-