143874-47-9Relevant academic research and scientific papers
Synthetic Studies on Duocarmycin. 1. Total Synthesis of dl-Duocarmycin A and Its 2-Epimer
Fukuda, Yasumichi,Itoh, Yoshio,Nakatani, Kazuhiko,Terashima, Shiro
, p. 2793 - 2808 (2007/10/02)
The title synthesis was first achieved by employing novel methoxycarbonylation of the C4-position of the 5-aminoindoline by way of the isatin and subsequent Dieckmann cyclization to the methyl 2-methylindoxyl-2-carboxylate as key steps.In vitro cytotoxicity assay against P388 murine leukemia obviously disclosed that cytotoxicities of the synthesized compounds are comparable and almost half of that of natural (+)-duocarmycin A. - Key Words: dl-duocarmycin A, dl-2-epi-duocarmycin A, total synthesis, antitumor antibiotic, cytotoxicity
First total synthesis of dl-duocarmycin A
Fukuda, Yasumichi,Nakatani, Kazuhiko,Ito, Yoshio,Terashima, Shiro
, p. 6699 - 6702 (2007/10/02)
The title synthesis could be achieved by featuring introduction of a methoxycarbonyl group into the C-4 position of a 5-aminoindoline nucleus by way of an isatin derivative and subsequent ring closure to a methyl 2-methylindoxyl-2-carboxylate system by the Dieckmann cyclization.
