143879-20-3

Upstream product

• 143879-18-9 (4S)-3-<(2R,3S,4R)-3-Hydroxy-2,5-dimethyl-4-phenylsulfanyl-1-oxohexyl>-4-(1-methylethyl)-1,3-oxazolidin-2-one 
• 132331-33-0 (S/R)-2-(phenylsulfanyl)-3-methylbutanal 

Downstream Products

• 17016-83-0 (4S)-4-isopropyl-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

Kinetic resolution in asymmetric anti aldol reactions of branched and straight chain racemic 2-phenylsulfanyl aldehydes: Asymmetric synthesis of cyclic ethers and lactones by phenylsulfanyl migration

The kinetic resolution of branched and straight chain 2-phenylsulfanyl aldehydes by the Lewis acid-catalysed asymmetric anti aldol reaction followed by reduction to single enantiomers of 1,3-diols and/or acid-catalysed cyclisation with PhS migration provides a route to enantiomerically pure cyclic ethers and lactones with full stereochemical control.

KINETIC RESOLUTIONS IN ANTI ALDOL REACTIONS: ASYMMETRIC SYNTHESIS OF HETEROCYCLES WITH PHENYLTHIO MIGRATION

Kinetic resolutions in Lewis acid catalysed asymmetric anti aldol reactions of the boron enolate of imide (2) with racemic 2-phenylthio aldehydes (3) give good yields of Felkin anti,anti aldols (6).The synthesis of homochiral cyclic ethers (4) and a simple novel route to homochiral lactones (5) are described.

Kinetic resolutions in anti aldol reactions with racemic 2-phenylthio aldehydes: Asymmetric synthesis of cyclic ethers and lactones with phenylthio migration

Kinetic resolutions in Lewis acid catalysed asymmetric anti aldol reactions of the boron enolate of imide (2) with racemic 2-phenylthio aldehydes (3a) - (3c) give good yields of anti,anti aldols (7). Synthesis of homochiral cyclic ethers (4a) - (4c) and (