143880-83-5

Upstream product

• 19811-05-3 2,4-dichlorobenzophenone 
• 3262-89-3 triphenylboroxine 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 98-80-6 phenylboronic acid 

Relevant academic research and scientific papers

Axially chiral C2-symmetric N-heterocyclic carbene (NHC) palladium complexes-catalyzed asymmetric arylation of aldehydes with arylboronic acids

Chiral C2-symmetric N-heterocyclic carbene (NHC) palladium diaquo complexes 5ac and the chiral C2-symmetric NHC-palladium complexes 5d and 5e prepared from (R)-BINAM or H8-(R)-BINAM could be used as the catalysts for the e

Asymmetric Transfer Hydrogenation of Diaryl Ketones with Ethanol Catalyzed by Chiral NCP Pincer Iridium Complexes

The use of a chiral (NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent. This reaction was applicable to various ortho-substituted diaryl keontes, affording benzhydrols in good yields and enantioselectivities. This protocol could be carried out in a gram scale under mild reaction conditions. The utility of the catalytic system was highlighted by the synthesis of the key precursor of (S)-neobenodine.

Asymmetric Hydrogenation of Polysubstituted Aromatic Ketones Catalyzed by the DIPSkewphos/PICA Derivative–Ruthenium(II) Complexes

The DIPSkewphos/PICA derivative-Ru(II) complexes catalyzed asymmetric hydrogenation of significantly sterically hindered 2’,3’,4’,5’,6’-pentamethylacetophenone, which was not reduced with NaBH4 at 25 °C, with a substrate-to-catalyst molar ratio

Synthesis of modular thiophene-oxazoline ligands and their application in the asymmetric phenyl transfer reaction to aldehydes

A series of thiophene mono (oxazoline) N,O-ligands with three sites of diversity were synthesized concisely in two steps from the corresponding thiophene carbonitriles. These ligands were applied to the enantioselective phenyl transfer reaction of aldehydes, resulting in the corresponding chiral diaryl methanol products with excellent yields and moderate to good enantioselectivities.

Catalyzed asymmetric aryl transfer reactions to aldehydes with boroxines as aryl source

Asymmetric aryl transfer of triphenylboroxin to a set of aryl aldehydes has been carried out in the presence of chiral amino alcohols derived from (S)-proline with high enantioselectivity. Substituted phenyl boroxins were also used as aryl source in asymmetric arylation of benzaldehyde.

Preparative syntheses of optically pure ortho-substituted benzhydrols by asymmetric reductions of the corresponding benzophenones

Lithium aluminium hydride previously treated with 2.5 equivalents of (S)-(+) or (R)-(-)-2-(2-iso-indolinyl)butan-1-ol 3 (readily available reagents) reduced the five ortho-substituted benzophenones 4-6, 8 and 10 into the corresponding optically active benzhydrols with nearly 100% enantiomeric excesses. Other examples of asymmetric reductions of prochiral benzophenones are given.