143882-72-8

Upstream product

• 2687-12-9 cinnamyl chloride 
• 143882-70-6 7-cinnamyloxy-8-iodocoumarin 
• 143882-67-1 7-hydroxy-8-(1'-phenylprop-2'-ene)coumarin 
• 65763-00-0 7-hydroxy-8-iodocoumarin 
• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 158758-44-2 7-(1-Methyl-2-oxo-2-phenyl-ethoxy)-chromen-2-one 

Relevant academic research and scientific papers

Dioxirane Oxidation of Furocoumarins and Naphthofurans. Preparation of the Psoralen Epoxides

Methyl(trifluoromethyl)dioxirane oxidation of natural psoralen (1a) and 8-methoxypsoralen (8-MOP, 1b) and dimethyldioxirane oxidation of some related 2,3-substituted furocoumarins 1c-e at subambient temperature afforded the corresponding labile epoxides 2

Furocoumarins: Part 34 - Synthesis and stereochemistry of dihydrofurocoumarins

7-Cinnamyloxy-4-methylcoumarin (1a) on Claisen rearrangement in N,N-dimethylaniline furnishes a cyclised angular dihydrofurocoumarin (4) and two open chain products (2 and 3a). 2 and 3a on cyclisation with conc.H2SO4 yield the corresponding dihydrofurocoumarins (8a and 11).Stereochemistry of dihydrofurocoumarins 4 and 8a has been studied using NOE difference spectra.Catalytic hydrogenation of 3,7-dimethyl-2-phenylfurobenzopyran-5(H)-one (6) and 2,7-dimethyl-3-phenylfurobenzopyran-5(H)-one (9a) furnish the corresponding cis isomers 7 and 10.Similarly,the stereochemistry of other dihydrofurocoumarins (12 and 3b) obtained by cyclisation of open chain products from Claisen rearrangement of 7-cinnamyloxy-8-iodo-coumarin were also studied.Furocoumarins 9b and 14 were also synthesised.