1438835-89-2Relevant academic research and scientific papers
Synthesis of new pyrazolo[1,5-a]pyrimidines by reaction of β,γ-unsaturated γ-alkoxy-α-keto esters with N-unsubstituted 5-aminopyrazoles
Stepaniuk, Oleksandr O.,Matviienko, Vitalii O.,Kondratov, Ivan S.,Vitruk, Igor V.,Tolmachev, Andrei O.
, p. 925 - 930 (2013)
The reaction of β,γ-unsaturated γ-alkoxy-α-keto esters with N-unsubstituted 5-aminopyrazoles was investigated. The reaction proceeds with high regioselectivity and is considered as an effective- method for the preparation of new pyrazolo[1,5-a]pyrimidines bearing an ester function in the 7-position. The obtained drug-like compounds have a great potential for medicinal chemistry as they closely resemble the structure of several marketed pharmaceuticals. Georg Thieme Verlag Stuttgart - New York.
