143887-40-5

Basic information

• Product Name: 2H-Imidazole-2-thione, 1,3-dihydro-4,5-bis[4-(1-methylethyl)phenyl]-
• CAS NO: 143887-40-5
• Molecular Formula: C21H24N2S
• Molecular Weight: 336.501
• Mol File: 143887-40-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2H-Imidazole-2-thione, 1,3-dihydro-4,5-bis[4-(1-methylethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Imidazole-2-thione, 1,3-dihydro-4,5-bis[4-(1-methylethyl)phenyl]-(143887-40-5)
• EPA Substance Registry System: 2H-Imidazole-2-thione, 1,3-dihydro-4,5-bis[4-(1-methylethyl)phenyl]-(143887-40-5)

Safety Data

• Hazardous Substances Data: 143887-40-5(Hazardous Substances Data)

Upstream product

• 122-03-2 (4-isopropylbenzaldehyde) 
• 5623-24-5 4,4'-diisopropylbenzoin 
• 17356-08-0 thiourea 

Relevant articles and documents

Acyl-CoA::cholesterol O-Acyl Transferase (ACAT) Inhibitors. 1. 2-(Alkylthio)-4,5-diphenyl-1H-imidazoles as Potent Inhibitors of ACAT

A potent, bioavailable ACAT inhibitor may have beneficial effects in the treatment of atherosclerosis by (i) reducing the absorption of dietary cholesterol, (ii) reducing the secretion of very low density lipoproteins into plasma from the liver, and (iii) preventing the transformation of arterial macrophages into foam cells.We have found that a mevalonate derivative 2, which contains a 4,5-diphenyl-1H-imidazol-2-yl moiety, inhibits rat hepatic microsomal ACAT in vitro and produces a significant hypocholesterolemic effect in the cholesterol-fed rat.Structure-activity relationships for analogues of 2 demonstrate that the 4,5-diphenyl-1H-imidazole moiety is a pharmacophore for inhibition of rat microsomal ACAT.