1438892-22-8Relevant academic research and scientific papers
Total synthesis of (±)-gelsemoxonine
Diethelm, Stefan,Carreira, Erick M.
, p. 8500 - 8503 (2013)
Gelsemoxonine (1) is a Gelsemium alkaloid incorporating an unusual azetidine. Its total synthesis was achieved employing a novel ring contraction of a spirocyclopropane isoxazolidine to furnish a β-lactam intermediate. This β-lactam ring was further elabo
Total Synthesis of Gelsemoxonine through a Spirocyclopropane Isoxazolidine Ring Contraction
Diethelm, Stefan,Carreira, Erick M.
, p. 6084 - 6096 (2015/05/27)
Plants of the species Gelsemium have found application in traditional Asian medicine for over a thousand years. Gelsemoxonine represents a novel constituent of this plant incorporating a highly functionalized azetidine at its core. We herein report a full
