1439365-86-2Relevant articles and documents
The synthesis of α,α-difluoroacetamides via electrophilic fluorination in the mixed-solvent of water and PEG-400
Zhang, Zhiguo,Bi, Jingjing,Liu, Qingfeng,Zhang, Guisheng
, p. 45 - 49 (2013/07/05)
Under mild conditions, a series of α,α-difluoro-β- ketoamides were synthesized with Selectfluor as the F + source in the presence of K2CO3 in the mixed-solvent of water and PEG-400 (VH2O:VPEG-400=3:1), without additional phase-transfer catalyst. By using this approach, most cases examined in this study proceeded in nearly quantitative conversions regardless of the electronic nature of the substituent pattern.
