1439368-18-9

Basic information

• Product Name: [4-(cyclohexyloxy)phenyl]methyl pyridin-2-yl carbonate
• Synonyms: [4-(cyclohexyloxy)phenyl]methyl pyridin-2-yl carbonate
• CAS NO: 1439368-18-9
• Molecular Weight: 327.38
• Mol File: 1439368-18-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: [4-(cyclohexyloxy)phenyl]methyl pyridin-2-yl carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(cyclohexyloxy)phenyl]methyl pyridin-2-yl carbonate(1439368-18-9)
• EPA Substance Registry System: [4-(cyclohexyloxy)phenyl]methyl pyridin-2-yl carbonate(1439368-18-9)

Safety Data

• Hazardous Substances Data: 1439368-18-9(Hazardous Substances Data)

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 1659-31-0 2,2'-dipyridyl carbonate 
• 13485-84-2 [4-(cyclohexyloxy)phenyl]methanol 

Relevant articles and documents

Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies

4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate (3b) is a potent, selective and systemically active inhibitor of intracellular NAAA activity, which produces profound anti-inflammatory effects in animal models. In the present work, we describe structure-activity relationship (SAR) studies on 3-aminoazetidin-2-one derivatives, which have led to the identification of 3b, and expand these studies to elucidate the principal structural and stereochemical features needed to achieve effective NAAA inhibition. Investigations on the influence of the substitution at the β-position of the 2-oxo-3-azetidinyl ring as well as on the effect of size and shape of the carbamic acid ester side chain led to the discovery of 3ak, a novel inhibitor of human NAAA that shows an improved physicochemical and drug-like profile relative to 3b. This favourable profile, along with the structural diversity of the carbamic acid chain of 3b, identify this compound as a promising new tool to investigate the potential of NAAA inhibitors as therapeutic agents for the treatment of pain and inflammation.

Synthesis, biological evaluation, and 3D QSAR study of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters as N -acylethanolamine acid amidase (NAAA) inhibitors

N-(2-Oxo-3-oxetanyl)carbamic acid esters have recently been reported to be noncompetitive inhibitors of the N-acylethanolamine acid amidase (NAAA) potentially useful for the treatment of pain and inflammation. In the present study, we further explored the