1439372-82-3

Upstream product

• 320592-10-7 (3aS,5S,6S,6aS)-6-(benzyloxy)-5-(benzyloxymethyl)-2,2-dimethyltetrahydrofuro[3,2-d][1,3]dioxole 
• 1439372-80-1 (2S,3R,4R,E)-1,3-bis(benzyloxy)-5-((R)-pent-4-en-2-ylamino)-7-phenylhept-6-ene-2,4-diol 
• 172949-42-7 (3aS,5S,6S,6aS)-5-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,2-d][1,3]dioxol-6-ol 
• 1439372-63-0 ((3aS,5S,6S,6aS)-6-acetoxy-2,2-dimethyltetrahydrofuro[3,2-d][1,3]dioxol-5-yl)methyl acetate 
• 144490-03-9 1,2,3,5-tetra-O-acetyl-β-L-ribofuranose 

Downstream Products

• 1439372-84-5 (1R,2S,3R,5R,8aR)-2-(benzyloxy)-3-(benzyloxymethyl)-5-methyl-1,2,3,5,6,8a-hexahydroindolizin-1-ol 

Relevant academic research and scientific papers

Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities

A concise synthesis of (-)-steviamine is reported along with the synthesis of its analogues 10-nor-steviamine, 10-nor-ent-steviamine and 5-epi-ent-steviamine. These compounds were tested against twelve glycosidases (at 143 μg mL-1 concentrations) and were found to have in general poor inhibitory activity against most enzymes. The 10-nor analogues however, showed 50-54% inhibition of α-l-rhamnosidase from Penicillium decumbens while one of these, 10-nor-steviamine, showed 51% inhibition of N-acetyl-β-d-glucosaminidase (from Jack bean) at the same concentration (760 μM). This journal is The Royal Society of Chemistry 2013.