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1439390-91-6

N,N'-(5,5′-thiobis(methylene)bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1439390-91-6 Structure

  • Basic information

    1. Product Name: N,N'-(5,5′-thiobis(methylene)bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)
    2. Synonyms: N,N'-(5,5′-thiobis(methylene)bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)
    3. CAS NO:1439390-91-6
    4. Molecular Formula:
    5. Molecular Weight: 496.638
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1439390-91-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N,N'-(5,5′-thiobis(methylene)bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)(CAS DataBase Reference)
    10. NIST Chemistry Reference: N,N'-(5,5′-thiobis(methylene)bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)(1439390-91-6)
    11. EPA Substance Registry System: N,N'-(5,5′-thiobis(methylene)bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)(1439390-91-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1439390-91-6(Hazardous Substances Data)

1439390-91-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1439390-91-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,3,9,3,9 and 0 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1439390-91:
(9*1)+(8*4)+(7*3)+(6*9)+(5*3)+(4*9)+(3*0)+(2*9)+(1*1)=186
186 % 10 = 6
So 1439390-91-6 is a valid CAS Registry Number.

1439390-91-6Downstream Products

1439390-91-6Relevant articles and documents

Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker

Duvall, Bridget,Elgogary, Amira,Gao, Run-Duo,Kal?ic, Filip,Le, Anne,Rais, Rana,Rojas, Camilo,Slusher, Barbara S.,Thomas, Ajit G.,Tsukamoto, Takashi,Veeravalli, Vijayabhaskar,Zimmermann, Sarah C.

, (2020)

A series of allosteric kidney-type glutaminase (GLS) inhibitors possessing a mercaptoethyl ([sbnd]SCH2CH2[sbnd]) linker were synthesized in an effort to further expand the structural diversity of chemotypes derived from bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES), a prototype allosteric inhibitor of GLS. BPTES analog 3a with a mercaptoethyl linker between the two thiadiazole rings was found to potently inhibit GLS with an IC50 value of 50 nM. Interestingly, the corresponding derivative with an n-propyl ([sbnd]CH2CH2CH2[sbnd]) linker showed substantially lower inhibitory potency (IC50 = 2.3 μM) while the derivative with a dimethylsulfide ([sbnd]CH2SCH2[sbnd]) linker showed no inhibitory activity at concentrations up to 100 μM, underscoring the critical role played by the mercaptoethyl linker in the high affinity binding to the allosteric site of GLS. Additional mercaptoethyl-linked compounds were synthesized and tested as GLS inhibitors to further explore SAR within this scaffold including derivatives possessing a pyridazine as a replacement for one of the two thiadiazole moiety.

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