1439396-18-5

Upstream product

• 4858-85-9 2,3-dichloropyrazine 
• 536-74-3 phenylacetylene 

Downstream Products

• 1439396-23-2 {1-[4-(6-phenyl-pyrrolo[2,3-b]pyrazin-5-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester 
• 1439396-16-3 1-[4-(6-phenyl-pyrrolo[2,3-b]pyrazin-5-yl)-phenyl]-cyclobutylamine 
• 1439396-21-0 {1-[4-(3-phenylethynyl-pyrazin-2-ylamino)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester 
• 66479-90-1 2-Phenylfuro<2,3-b>pyrazine 

Relevant academic research and scientific papers

1,3-Dipolar cycloaddition of azinium ylides to alkynyl hetarenes: A synthetic route to indolizine and pyrrolo[2,1-a]isoquinoline based heterobiaryls

For the first time, π-deficient alkynyl hetarenes were used as dipolarophiles in a 1,3-dipolar cycloaddition reaction with in situ generated azinium ylides. A three-component reaction of pyridine or isoquinoline, ethyl chloroacetate and alkynyl hetarene (

Synthesis and Characterization of Pyridine-, Pyrazine-, and Quinoxaline-Derived [4]Helicenes and S-Shaped Double [4]Helicenes

A systematic study of the synthesis and properties of 1-aza-, 4-aza-, and 1,4-diaza[4]helicenes as well as the previously unknown S-shaped double 1,4-diaza[4]helicenes has been reported. The synthetic route to the aza- and diaza[4]helicenes involved an el

Synthesis and Characterization of Azine-[5]Helicene Hybrids

Novel azine-helicene hybrids (pyridine-, pyrazine- and quinoxaline-fused along the central ring [5]helicenes) have been prepared in good overall yields through a five-step synthetic sequence. Commercially available 2,3-dihaloazines were used as starting materials. To discern the effect of merging an azine moiety within a helical skeleton, the X-ray structures, UV/Vis absorption spectra, cathodic and anodic electrochemistry of the helicene hybrids were investigated and compared to that of the parent [5]helicene.

Synthesis, crystal structures and properties of carbazolebased [6]helicenes fused with an azine ring

Novel carbazole-based [6]helicenes fused with an azine ring (pyridine, pyrazine or quinoxaline) have been prepared through a fivestep synthetic sequence in good overall yields. Commercially available 2, 3-dihaloazines were used as starting materials. To d

Trifluoroacetic Acid Mediated One-Pot Synthesis of Furo-Fused Quinoxalines/Pyrazines

A trifluoroacetic acid promoted step-economical one-pot approach to the synthesis of furo-fused quinoxalines/pyrazines by the reaction of 2,3-dichloroquinoxalines/pyrazines with alkynes is described. The reaction involves a selective in-situ Sonogashira c

Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: An unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis

The link between PDE4 and apoptosis prompted us to design and synthesize for the first time a series of novel 1-thienyl pyrroloquinoxalines as potential PDE4 inhibitors/apoptotic agents. A ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy h

BICYCLIC HETEROARYL DERIVATIVES AS KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula 1: wherein Het, X, R1 and R2 are as defined herein.

Transition metal free hydrolysis/cyclization strategy in a single pot: Synthesis of fused furo N-heterocycles of pharmacological interest

A transition metal free tandem two-step strategy has been developed involving hydrolysis of 2-chloro-3-alkynyl quinoxalines/pyrazines followed by in situ cyclization of the corresponding 2-hydroxy-3-alkynyl intermediates in a single pot leading to fused furo N-heterocycles as potential inhibitors of sirtuins. A representative compound showed promising pharmacological properties in vitro and in vivo.