143946-49-0

Basic information

• Product Name: Quinoline, 4-chloro-5,7-dimethoxy-
• Synonyms: Quinoline, 4-chloro-5,7-dimethoxy- ;4-chloro-5,7-dimethoxyquinoline
• CAS NO: 143946-49-0
• Molecular Formula: C11H10ClNO2
• Molecular Weight: 223.6556
• Mol File: 143946-49-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Quinoline, 4-chloro-5,7-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 4-chloro-5,7-dimethoxy-(143946-49-0)
• EPA Substance Registry System: Quinoline, 4-chloro-5,7-dimethoxy-(143946-49-0)

Safety Data

• Hazardous Substances Data: 143946-49-0(Hazardous Substances Data)

Usage

General Description

Quinoline, 4-chloro-5,7-dimethoxy- is a chemical compound with a quinoline backbone and chloro- and methoxy- substituents. It is a heterocyclic organic compound that has a variety of applications. It is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and also as a building block in the development of new compounds. It may also have some industrial and research applications, although its specific uses may vary. Quinoline, 4-chloro-5,7-dimethoxy- has a yellowish color and a distinct odor, and its properties and reactivity make it an important molecule in the field of organic chemistry.

Upstream product

• 10272-07-8 3.5-dimethoxyaniline 
• 1071540-44-7 5,7-dimethoxyquinolin-4(1H)-one 

Downstream Products

• 1437323-77-7 4-(5,7-dimethoxyquinolin-4-yloxy)phenylamine 
• 1437323-76-6 5,7-dimethoxy-4-(4-nitrophenoxy)quinoline 

Relevant articles and documents

Aurora Kinase Modulators and Method of Use

The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

QUINOLINE DERIVATIVES

The invention concerns quinoline derivatives of Formula I or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.