143958-71-8

Usage

Chemical class

Purines, which are heterocyclic aromatic compounds.

Derivative

1H-Purine-2,6-dione, 3,7-dihydro-3,7-bis[(4-methoxyphenyl)methyl]is a derivative of purine.

Methoxyphenylmethyl groups

Two methoxyphenylmethyl groups are attached to the 3 and 7 positions of the purine ring.

Dihydro structure

The presence of two hydrogen atoms added across the double bond of the purine ring.

Potential applications

Medicinal chemistry and pharmaceutical research.

Unique structure and properties

The compound's structure and properties may offer opportunities for developing novel drugs or understanding biological functions related to purines.

Upstream product

• 143958-70-7 3,7-dihydro-3-(4-methoxybenzyl)-1H-purine-2,6-dione 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 143958-72-9 1-ethyl-3,7-dihydro-3,7-bis(4-methoxybenzyl)-1H-purine-2,6-dione 
• 104285-82-7 1-Propylxanthine 
• 1027572-70-8 3,7-Bis-(4-methoxy-benzyl)-1-propyl-3,7-dihydro-purine-2,6-dione 
• 1027664-57-8 1-Butyl-3,7-bis-(4-methoxy-benzyl)-3,7-dihydro-purine-2,6-dione 

Relevant academic research and scientific papers

Effects of Alkyl Substitutions of Xanthine Skeleton on Bronchodilation

Structure-activity relationships in a series of 1,3,7-trialkyl-xanthine were studied with guinea pigs.Relaxant actions in the tracheal muscle were increased with alkyl chain length at the 1- and 3-positions of the xanthine skeleton, but decreased by alkylation at the 7-position.Positive chronotropic actions in the right atrium were potentiated with 3-alkyl chain length but tended to decrease with 1-alkylation and diminish by 7-substitution.Consequently, while the 1- and 3-substitutions were equally important for the tracheal smooth muscle relaxation, the substitution at the 1-position was more important than the 3-substitution for bronchoselectivity.The 7-alkylation may be significant to cancel heart stimulation.There were good correlations between the smooth muscle relexant action and the cyclic AMP-PDE inhibitory activity in 3-substituents and the affinity for adenosine (A1)receptors in 1-,3-, and 7-substituents.This suggests that not only the cyclic AMP-PDE inhibitory activity but also the adenosine antagonistic activity is important in the bronchodilatory effects of alkylxanthines.Among these xanthine derivatives, 1-butyl-3-propylxanthine and its 7-methylated derivative showed high bronchoselectivity in the in vitro and in vivo experiments compared to theophylline and enprofylline and may be new candidates for bronchodilator.