143966-57-8

Basic information

• Product Name: N-T-BOC-L-SERINE ALLYL ESTER
• Synonyms: N-T-BOC-L-SERINE ALLYL ESTER;N-[(1,1-DiMethylethoxy)carbonyl]-L-serine 2-Propen-1-yl Ester
• CAS NO: 143966-57-8
• Molecular Formula: C₁₁H₁₉NO₅
• Molecular Weight: 245.27
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Chiral Reagents
• Mol File: 143966-57-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: N-T-BOC-L-SERINE ALLYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: N-T-BOC-L-SERINE ALLYL ESTER(143966-57-8)
• EPA Substance Registry System: N-T-BOC-L-SERINE ALLYL ESTER(143966-57-8)

Safety Data

• Hazardous Substances Data: 143966-57-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Oil

Upstream product

• 2766-43-0 N-tert-butyloxycarbonyl-L-serine methyl ester 
• 107-18-6 allyl alcohol 
• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 106-95-6 allyl bromide 

Downstream Products

• 959415-39-5 (R)-2-((tert-butoxycarbonyl)amino)-3-((4-methoxybenzyl)selanyl)propanoic acid 
• 877754-71-7 (2R,2'R)-3,3'-diselanediylbis(2-((tert-butoxycarbonyl)amino)propanoic acid) 
• 1160510-88-2 C₃₈H₄₆N₂O₁₁ 
• 865701-97-9 3-bromo-2-tert-butoxycarbonylamino-propionic acid allyl ester 
• 1346693-96-6 (O-(N-((9-fluorenylmethoxy)carbonyl)-N-phenyl)aminomethyl)-N-(6-(2,4-dinitrophenyl)amino)hexanoyl-L-serine allyl ester 
• 1346434-12-5 N-(6-(2,4-dinitrophenyl)amino)hexanoyl-L-serine allyl ester 

Relevant articles and documents

Active carbonate resins for solid-phase synthesis through the anchoring of a hydroxyl function. Synthesis of cyclic and alcohol peptides

N,N'-Disuccinimidyl carbonate (DSC) has been successfully used for the efficient conversion of 4-hydroxymethylpolystyrene and 4-hydroxymethyl-3-nitrobenzamido (Nbb) resins into active carbonate resins, which are suitable for the incorporation of molecules

Oxidative deselenization of selenocysteine: Applications for programmed ligation at serine

Despite the unique chemical properties of selenocysteine (Sec), ligation at Sec is an under-utilized methodology for protein synthesis. We describe herein an unprecedented protocol for the conversion of Sec to serine (Ser) in a single, high-yielding step.

CONTROLLED RELEASE FROM MACROMOLECULAR CONJUGATES

The invention relates to conjugates of macromolecular carriers and drugs comprising linkers that release the drug or a prodrug through rate-controlled beta-elimination, and methods of making and using the conjugates.

Polymer-supported O-benzyl and O-allylisoureas: Convenient preparation and use in ester synthesis from carboxylic acids

Polymer-supported O-methyl, O-benzyl, and O-allyl-isoureas were prepared by copper(II)-catalyzed reaction of polymer-supported carbodiimide with the corresponding alcohols. These polymer-supported reagents were successfully employed to convert a series of carboxylic acids to methyl, benzyl, or allyl esters, in good yields. The products were obtained with high purity (>95% by NMR) after a simple resin filtration-solvent evaporation sequence.