143978-86-3 Usage
Uses
Used in Pharmaceutical Industry:
(R)-2-tert-Butoxycarbonylamino-3-methanesulfonyl-3-methyl-butyric acid is used as a key intermediate in the synthesis of peptide-based drugs. The presence of the Boc protecting group allows for the protection and subsequent deprotection of amino groups during peptide synthesis, which is crucial for the successful assembly of complex peptide structures.
Additionally, the methanesulfonyl group in (R)-2-tert-Butoxycarbonylamino-3-methanesulfonyl-3-methyl-butyric acid can act as a leaving group in various chemical reactions, making it a valuable component in the development of new pharmaceutical agents.
Used in Peptide Synthesis:
In the field of peptide synthesis, (R)-2-tert-Butoxycarbonylamino-3-methanesulfonyl-3-methyl-butyric acid is used as a building block for creating novel peptide sequences. The Boc protecting group ensures that the amino group remains protected during the synthesis process, preventing unwanted side reactions and allowing for the controlled stepwise assembly of the peptide chain.
Furthermore, the methanesulfonyl group can be utilized in various chemical reactions to introduce different functional groups or modify the peptide structure, thus expanding the range of potential applications for the synthesized peptides.
Check Digit Verification of cas no
The CAS Registry Mumber 143978-86-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,9,7 and 8 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 143978-86:
(8*1)+(7*4)+(6*3)+(5*9)+(4*7)+(3*8)+(2*8)+(1*6)=173
173 % 10 = 3
So 143978-86-3 is a valid CAS Registry Number.
143978-86-3Relevant academic research and scientific papers
Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents
Niu, Chuan,Smith, Daniel,Zask, Arie,Loganzo, Frank,Discafani, Carolyn,Beyer, Carl,Greenberger, Lee,Ayral-Kaloustian, Semiramis
, p. 4329 - 4332 (2007/10/03)
Modifications of the B-segment of HTI-286 (2) produced a class of analogs incorporating heteroatom-substituents. The structure-activity relationship was studied. Analogs bearing methylsulfide and fluoride groups exhibited potency comparable to that of the parent compound HTI-286 and to paclitaxel in cytotoxicity assays against KB-3-1 cell lines. These analogs were more potent than paclitaxel against P-glycoprotein expressing KB-8-5 and KB-V1 cell lines. Several analogs showed strong inhibition of tubulin polymerization.
