1439792-74-1Relevant academic research and scientific papers
Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension
Bauman, David R.,Whitehead, Alan,Contino, Lisa C.,Cui, Jisong,Garcia-Calvo, Margarita,Gu, Xin,Kevin, Nancy,Ma, Xiuying,Pai, Lee-Yuh,Shah, Kashmira,Shen, Xiaolan,Stribling, Sloan,Zokian, Hratch J.,Metzger, Joe,Shevell, Diane E.,Waddell, Sherman T.
, p. 3650 - 3653 (2013/07/25)
In an effort to understand the origin of blood-pressure lowering effects observed in recent clinical trials with 11β-HSD1 inhibitors, we examined a set of 11β-HSD1 inhibitors in a series of relevant in vitro and in vivo assays. Select 11β-HSD1 inhibitors reduced blood pressure in our preclinical models but most or all of the blood pressure lowering may be mediated by a 11β-HSD1 independent pathway.
