14398-95-9

Basic information

• Product Name: Ethyl 1-Methylpyrrolidine-3-carboxylate
• Synonyms: Ethyl 1-Methylpyrrolidine-3-carboxylate
• CAS NO: 14398-95-9
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.2102
• Mol File: 14398-95-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 187.9°C at 760 mmHg
• Flash Point: 66.7°C
• Appearance: /
• Density: 1.021g/cm³
• Vapor Pressure: 0.617mmHg at 25°C
• Refractive Index: 1.461
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 1-Methylpyrrolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 1-Methylpyrrolidine-3-carboxylate(14398-95-9)
• EPA Substance Registry System: Ethyl 1-Methylpyrrolidine-3-carboxylate(14398-95-9)

Safety Data

• Hazardous Substances Data: 14398-95-9(Hazardous Substances Data)

Usage

Uses

Ethyl 1-methylpyrrolidine-3-carboxylate is a useful intermediate for organic synthesis.

InChI:InChI=1/C8H15NO2/c1-3-11-8(10)7-4-5-9(2)6-7/h7H,3-6H2,1-2H3

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Relevant articles and documents

Nonstabilized Azomethine Ylides in the Mannich Reaction: Synthesis of 3,3-Disubstituted Pyrrolidines, Including Oxindole Alkaloids

Active methylene compounds react with in situ generated nonstabilized azomethine ylides via the domino Mannich reaction-dipolar cycloaddition to form 3,3-disubstituted pyrrolidines, including oxindole alkaloids. When the starting material possesses a single activated hydrogen, the reaction terminates at the Mannich base stage. The developed methodology was applied to a short and efficient synthesis of (±)-horsfiline and N-protected (±)-coerulescine.